Underlying worldview
We are entering the era of unpredictability. Not because something in the fundamental laws of physics started to change suddenly, but a number of other reasons -- most of which can be packed under the categories of reflexivity, hyper-connectivity and accelerating change (see paper).
The above entails (jumping over a few steps of argumentation, which can be found in papers) that we cannot any more assume that the world is a predictable system -- worse than that, it is not useful even to base our thinking on the premise that it approximates a deterministic system.
One of the reasons for rejecting determinacy in our thinking is that a complex system with high volatility cannot be truly represented by or simplified to a single model. A single model implies single observer of the system with a global view to it. The relaxation of assumption that there could be a single best model describing a system is equivalent to saying that there could be not global observer with 'the best' perspective / overview of the system's events.